From Latin 'calix' (cup, goblet), possibly related to Greek 'kylix' — gained its Christian liturgical sense in church Latin.
A large cup or goblet, typically used for drinking wine; specifically, the cup used to hold the wine consecrated in the Christian Eucharist.
From Anglo-Norman 'chalice' and Old French 'calice,' from Latin 'calicem,' accusative of 'calix' (cup, goblet). Latin 'calix' is of uncertain ultimate origin but may be borrowed from Greek 'kýlix' (κύλιξ), a type of drinking cup. Some scholars alternatively connect it to an Indo-European root meaning 'cup
Latin had two near-homonyms: 'calix' (cup, with a short 'a') and 'calyx' (the outer covering of a flower bud, borrowed from Greek 'kályx,' husk). The two words have completely different origins — one refers to drinking vessels, the other to botanical structures — but their similarity has caused confusion for centuries, and some medieval manuscripts mix them up.